Proteomics and Protein Analysis Core (PRO)

Proteomics and Protein Analysis 

The Meharry Proteomics and Protein Analysis Core (PRO) provides comprehensive bottom-up Proteomic services on the Orbitrap platform with optional MudPIT, isobaric tag labeling (SILAC or TMT/iTRAQ), and PTM analysis. Additional services include protein separation and analysis with UHPLC or FPLC, and SPR analysis for protein binding. 

Equipment:

  1. Thermo Orbitrap Exploris 120 mass spectrometer with UltiMate 3000 RSLC nano-chromatograph for Proteomics and LC-MS analysis 
  2. Thermo Proteome Discoverer software 
  3. Bio-Rad NGC 100 FPLC system with fraction collector  
  4. Agilent 1260 Infinity II UHPLC system 
  5. Nicoya OpenSPR instrument 

Proteomics and LC-MS Services:

  1. Shotgun Proteomics analysis (gel-based or liquid samples) with optional PTM analysis  
  2. 10-step MudPIT with label-free, SILAC or TMT/iTRAQ quantification for complex biological samples (full cell lysates or tissue homogenates) 
  3. Targeted small molecule LC-MS analysis with optional absolute quantitation using deuterated internal standards  
  4. Protein separation/analysis with FPLC or UHPLC 
  5. Protein binding studies with SPR (surface plasmon resonance)  
  6. Proteomics data analysis, training, and consulting  

Contact Us: 

Dr. Victor Paromov

Victor Paromov, Ph.D.

Director, PRO Core

vparomov@mmc.edu

For reservations and a free consultation, register on the Meharry iLab site iLab Organizer :: login.  

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