The Retinal Imaging Core provides advanced in vivo imaging and functional assessment tools to support vision science research. It enables high-resolution visualization and quantification of retinal structure and function in small animal models, particularly mice and rats. The core is equipped with state-of-the-art systems for structural imaging, functional testing, and disease modeling.
Instrumentation
1. Micron V Retinal Imaging System: Manufacturer: Phoenix Research Labs
The Micron V is a high-resolution retinal imaging system optimized for small animal models. It supports a wide range of imaging modalities and is particularly well-suited for disease modeling and longitudinal studies
The Celeris system is a compact, non-invasive platform for assessing retinal and visual pathway function in small animals. It uses contact lens electrodes and integrated light stimulation to record electrical responses from the retina and brain.
Functional Assessments:
Rod and Cone Photoreceptor Responses: Measures scotopic (rod-mediated) and photopic (cone-mediated) ERG waveforms to evaluate photoreceptor integrity.
Pattern ERG (PERG): Assesses retinal ganglion cell (RGC) function using contrast-reversing stimuli; useful for detecting early glaucomatous changes.
C-Wave Recording: Captures the C-wave, a slow positive potential reflecting retinal pigment epithelium (RPE) activity.
Ideal for longitudinal studies and pharmacological testing.
3. OptoDrumPlus Visual Stimulation System : Manufacturer: Striatech
The OptoDrumPlus is a digital optokinetic tracking (OKT) system used to assess visual function in rodents.
Capabilities:
Visual Acuity Testing: Measures the highest spatial frequency at which the animal tracks motion.
Contrast Sensitivity: Evaluates the lowest contrast level detectable by the animal.
Automated Head Tracking: Real-time detection of reflexive head movements in response to rotating stimuli.
