The Tennessee Center for AIDS Research (TN-CFAR) leverages complementary strengths of its four partner institutions to have broad and substantial impact on the HIV epidemic. Through this four-way partnership between Vanderbilt University Medical Center, Meharry Medical College, the Tennessee Department of Health, and Nashville CARES, our vision is to have transformative local and global translational impact. Guided by this vision, our mission is to coordinate the institutional and community strengths and resources of VUMC, MMC, TDH, and CARES to most effectively reduce the burden of HIV/AIDS and generalize these benefits worldwide.